Description
CD22, also known as B-cell receptor CD22 isoform 1, is a member of the immunoglobulin (Ig) superfamily. It mediates B-cell to B-cell interactions and is involved in the localization of B-cells in lymphoid tissues. This protein plays a positive regulation through interaction with Src family tyrosine kinases and also acts as an inhibitory receptor by recruiting cytoplasmic phosphatases. Recombinant human CD22 protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques